While precision drugs can revolutionize health care, it requires access to an unprecedented volume and variety of information, and an infrastructure that rapidly brings new discoveries to bear. Recently, we revealed an article in theJournal of the American Medical Informatics Associationthat describes health IT’s important function in precision medication based on key insights from a collection ofONC projectssupporting the Precision Medicine Initiative. Health fairness andsocial determinants of health knowledge had been a recurring theme at this 12 months’sONC Annual Meeting. Leveraging these essential knowledge, which reflect the place people are born, live, be taught, work and play can have a …